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Title NEw Targets in DIAstolic heart failure: from coMOrbidities to persoNalizeD medicine
Reference POCI-01-0145-FEDER-016385
PI José Luís Oliveira
Participants Armando J. Pinho, Raquel Silva
Funded by COMPETE 2020
Global funding (€) 2,500,000€3,450,000 USD
RU funding (€) 198,000€273,240 USD
Starts 2016/12/01
Ends 2019/11/30

NETDIAMOND joins a network of national centres of reference with complementary expertizes to address this novel and highly relevant issue: the development of evidence-based therapeutic strategies directed at heart failure (HF) with preserved ejection fraction (HFpEF). The research of the IEETA team is centered in two main objectives: 1) Analysis of omics data from myocardial samples – the main goal is to create and conduct a data analisys pipeline that leads to the identification of gene variants, and of gene and protein expression patterns. 2) Data integration, data processing and mining – the objective are (a) the construction of a systems biology view of HFpEF and the role of comorbidities; (b) identification of main pathways and elements in HFpEF and their disturbances with comorbidities; (3) clinical correlation of molecular findings (diagnostic and prognostic biomarkers).